Obstructive Sleep Apnea Syndrome
Conditions
Interventions
OSA cognitive impairment group :None
OSA without cognitive impairment group:None
Sponsors
Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: All subjects, regardless of gender, aged 18-65, voluntarily participated in the project and met the requirements for each group. Informed consent was obtained from each subject before the study, and they signed an informed consent form. This study followed the principles of the Declaration of Helsinki. All subjects were divided into three groups: 1. Healthy Control Group (H group): 30 healthy volunteers were recruited in the Wuxi area, and saliva samples were collected from the volunteers; 2. OSA without cognitive impairment group (O group): Select 30 patients diagnosed with OSA by our hospital's doctors through polysomnography and assessed with the MoCA scale as having no related cognitive dysfunction. Collect saliva samples from the patients; 3. OSA with Cognitive Impairment Group (S group): 30 patients diagnosed with OSA by our hospital doctors through PSG and assessed to have cognitive impairment using the MoCA scale. Saliva samples were collected from these patients. Each cognitive function assessor was trained by a neurologist.
Exclusion criteria
Exclusion criteria: 1. Severe systemic diseases (such as heart, liver, or kidney failure); 2. Mental illnesses (such as depression, mania, schizophrenia); 3. Neurological disorders (such as head trauma, brain tumor, epilepsy, stroke, transient ischemic attack, coma); 4. Drug addiction, use of psychotropic drugs, current use of sedatives or anesthetics; 5. Previous treatment for OSA (such as CPAP, upper airway surgery, oral appliances); 6. Severe periodontitis, Sjogren's syndrome, oral ulcers, presence of dentures or other oral diseases; 7. Inappropriate lifestyle habits and medical history, including vegan diet, periodontal treatment in the past 6 months, and use of antibiotics in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in oral microbial a/ß diversity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Untargeted Metabolite Quantification; | — |
Countries
China
Contacts
Public ContactHu Na
Affiliated Hospital of Jiangnan University
Outcome results
None listed