Laparoscopic Cholecystectomy
Conditions
Interventions
Dexmedetomidine Group: After anesthesia induction, dexmedetomidine was immediately infused at a rate of 0.4 µg/kg/h (200 µg of dexmedetomidine diluted with normal saline to form a 20 mL solution), and
Control Group:After anesthesia induction, the same rate of normal saline (20 mL) was pumped continuously. The pumping was stopped when suturing the skin.
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. 18 - 65 years old (including the boundary values). 2. Patients diagnosed with gallbladder stones/ gallbladder inflammation. 3. ASA classification I-II. 4. Patients undergoing elective laparoscopic cholecystectomy. 5. Voluntary participants in this study and who have signed the informed consent form. If the subject is unable to read the informed consent form (such as illiterate subjects), then a witness is required to witness the informed process and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergic to opioids, local anesthetics, and dexmedetomidine. 2. Patients who have been taking opioids for a long time or are drug-dependent (for more than 3 months). 3. Patients with long-term chronic pain (within 3 months before the surgery, any chronic pain score (such as NRS) >= 4 points, or requiring regular use of analgesics). 4. Patients with acute or severe bronchial asthma, patients with severe sleep apnea syndrome. 5. Known or suspected gastrointestinal obstruction (including paralytic ileus). 6. Patients with severe cardiac conduction block (such as second-degree or above atrioventricular conduction block) without a pacemaker. 7. Patients with severe hypotension, shock or uncorrected blood loss. 8. Pregnant or lactating women. 9. Vulnerable groups other than illiterates, including critically ill patients, patients with mental disorders, patients with cognitive impairment, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ED50 and ED95 of taliglide for preventing acute pain after laparoscopic cholecystectomy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain scores (NRS scores) after extubation;The incidence of nausea and vomiting 12 hours after the operation;The incidence of itching;The incidence of hypoxemia;Patient satisfaction score for pain relief;Rate of remedial analgesia; | — |
Countries
China
Contacts
Public ContactChen Gang
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed