Stroke
Conditions
Interventions
Channel 2: 2010 Hz
active stimulation group:For the active stimulation group, the stimulation parameters were set as follows: Channel 1: 2000 Hz
current intensity: 2 mA. Both the ramp-up and ramp-down phases lasted 30 seconds respectively, with a single stimulation session of 30 minutes. Silver/silver chloride sintered electrodes were selected
the anode of Channel 2 was placed at the posterior aspect of the scalp projection area of the same target (5 mm anterior and 3 mm superior to the T7 electrode site in the 10-20 system). The distance b
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
35 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Conforms to the diagnostic criteria for stroke adopted at the 4th National Cerebrovascular Disease Conference 2. Confirmed as stroke by cranial CT or MRI, with lesions located in the subcortical structures and restricted to the left cerebral hemisphere 3. First-onset stroke; no abnormalities in speech or cognitive function prior to the onset of the disease 4. Definite presence of subcortical lesions confirmed by cranial CT or MRI, and diagnosed as subcortical aphasia in combination with the Western Aphasia Battery (WAB) 5. Disease duration of 2 weeks to 1 year 6. Aged 35–80 years 7. Native language is Mandarin Chinese 8. Clear consciousness and able to complete scale-based assessments 9. Classified as right-handed according to the Edinburgh Handedness Inventory (EHI) 10. For participants receiving medications to improve cognition/speech (e.g., donepezil, memantine) or antidepressants, no dose adjustment shall be performed during the enrollment period.
Exclusion criteria
Exclusion criteria: 1. Subjects with coma, disturbance of consciousness, severe cognitive impairment, or other conditions that prevent cooperation with examinations. 2. Subjects complicated with severe cardiac, hepatic or renal dysfunction, severe internal diseases, or other disorders that affect language function. 3. Subjects with non-first-onset stroke, or a history of mental illness, drug dependence or alcohol dependence. 4. Subjects with contraindications to MRI scanning, such as metallic foreign bodies like cardiac pacemakers or stents implanted in the body, or a diagnosis of claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| western aphasia battery,WAB score; | — |
Secondary
| Measure | Time frame |
|---|---|
| non-language-based cognlitive assessment,NLCA score;modified barthel index,MBI score;Amplitude of Low-Frequency Fluctuations in functional Near-Infrared Spectroscopy;Functional Connectivity in functional Near-Infrared Spectroscopy; | — |
Countries
China
Contacts
Public ContactHu Xiquan
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed