Insonmia
Conditions
Interventions
A group:Intranasal spray of dexmedetomidine
B group:Intravenous injection of dexmedetomidine.
Sponsors
Shanghai Fourth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–65 years, male or female. 2. Meets the diagnostic criteria for insomnia according to ICSD-3 or DSM-5. 3. Normal liver and kidney function (within the normal reference range) and no severe arrhythmia on electrocardiogram (ECG). 4. Agreement to participate in the study and provision of signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Diagnosed with a major systemic disease within the past 6 months or currently undergoing treatment for such a condition. 2. History of allergy to dexmedetomidine. 3. Female subjects who are pregnant or lactating. 4. Failure to provide written informed consent, or provision of consent but presence of severe cognitive impairment, language communication barriers, or inability to cooperate with polysomnography (PSG) monitoring as assessed by the investigator. 5. Patients with hepatic or renal insufficiency, bradycardia, or hypotension. 6. A history of alcohol abuse, substance abuse within the past 3 months, or current smokin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep Stage;Concentration-time curve; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep latency;Total sleep time;Number of arousal;Wake After Sleep Onset; | — |
Countries
Chian
Contacts
Public ContactQifang Li
Shanghai Fourth People‘s Hospital
Outcome results
None listed