Type 2 diabetes mellitus
Conditions
Interventions
GLP-1RA hypoglycemic treatment group:None
SGLT-2 inhibitor treatment group:None
Dipeptidyl peptidase-4 hypoglycemic drug treatment group:None
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged >=40 years; 2.Provided written informed consent for the study protocol; 3.Diagnosed with type 2 diabetes mellitus (T2DM) according to the WHO 1999 criteria; 4.Possessed complete and detailed clinical information;
Exclusion criteria
Exclusion criteria: 1.Inability to cooperate with or complete the MoCA cognitive assessment or 3.0T cranial MRI scanning; 2.Presence of endocrine diseases other than T2DM that could significantly affect blood glucose levels; 3.Severe cerebrovascular or intracranial conditions that could affect neuroimaging structural analyses, including cerebral infarction, hemorrhage, trauma, or tumors; 4.History of any condition potentially impacting cognitive function, such as thyroid disorders, malignant tumors, severe alcoholism, psychiatric disorders, major infections, acute diabetic complications, severe hepatic, cardiac, or renal diseases, major trauma, or pregnancy; 5.Left-handedness; 6.Any contraindications to MRI scanning;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The oxidative stress indicators include malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR).;Subcortical segmentation and cortical volume (Grey matter volume, GMV), cortical thickness (CT), and surface area (SA) of bilateral brain regions according to the Desikan-Killiany atlas.; | — |
Countries
China
Contacts
Public ContactWenjun Wu
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed