Osteoarthritis
Conditions
Interventions
Group 1:Participants will maintain their habitual lifestyle throughout the study period and will not receive any structured exercise intervention, including resistance training or aerobic training. On
Group 2:Participants will undergo a structured upper-limb resistance training program targeting the major upper-limb skeletal muscle groups, including the biceps brachii, triceps brachii, deltoid, pec
Group 3:Participants will undergo a structured lower-limb resistance training program targeting the major lower-limb skeletal muscle groups, including the quadriceps, hamstrings, gluteus maximus, and
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Clinically diagnosed with knee osteoarthritis, with the Kellgren-Lawrence grade of the affected knee confirmed by imaging as grade IV, or proposed to receive total knee arthroplasty (TKA) treatment after preoperative assessment; Or have symptoms related to knee osteoarthritis, and have the ability to participate in exercise intervention experiments; 2. No serious neurological, cardiovascular, respiratory or mental system diseases, and passed the preoperative/pre-exercise safety screening assessment; 3. No glucocorticoid drug treatment was received within 3 months before the operation; 4. No history of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus; 5. No history of active infection or malignant tumor; 6. Be capable of cooperating to complete the process of biological sample collection or exercise intervention; 7. Understand the purpose and process of this study and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Diagnosed with autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus; 2. Within 3 months before the operation, received glucocorticoids, intra-articular injections or other treatments that might affect the research results; 3. Those with severe cardiovascular, neurological or mental system diseases who cannot tolerate exercise or surgery; 4. Have cognitive impairments, poor compliance, and are unable to complete the research process or cooperate with the follow-up. 5. Those with active infections or those who have recently undergone major joint surgery; 6. Other circumstances where the researcher deems it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight;Height;Clinical score;Body composition; | — |
Secondary
| Measure | Time frame |
|---|---|
| age;gender;Maximal oxygen uptake; | — |
Countries
China
Contacts
Public ContactGu Cheng
The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed