Schizophrenia with cognitive impairment
Conditions
Interventions
Active ?-tTIS group:Active ?-tTIS
Sham ?-tTIS group:Sham ?-tTIS
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria for schizophrenia according to the DSM-5; 2. Aged 18-60 years; 3. A total PANSS score of >=60, with a score of >=10 on the Positive Scale and a score of >=7 on the Negative Scale. 4. Willing to participate and sign the informed consent. 5. No clinically significant abnormalities or stable and controllable conditions in physical examination, medical history, vital signs, routine blood and urine tests, liver and kidney function, electrolytes, electrocardiogram (ECG), electroencephalogram (EEG), or other indicators; 6. Antipsychotic medication regimen stable for at least 4 weeks and dose stable for at least 2 weeks;
Exclusion criteria
Exclusion criteria: 1. Severe agitation or self/other harm risk. 2. Intracranial metal implants, history of epilepsy/seizure induction, pacemakers, or other contraindications for electrical stimulation; 3. Received electroconvulsive therapy in the past month; 4. Pregnancy or breastfeeding; 5. History of alcohol or other substance abuse, or severe physical illness; 6. Visual impairment that prevents completion of cognitive behavioral tasks;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive-behavioral task indices, such as accuracy and reaction time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Scores of the Adverse Event Record Form;cognitive function and clinical symptoms;Neurophysiological indicators drived from eletropgysiology and neuroimaging; | — |
Countries
China
Contacts
Public ContactWang Yucheng
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed