Digestive system disease
Conditions
Interventions
Trial group:The patient received intravenous administration of snake venom thrombin (twice daily, 1 unit each time, for 72 hours) in combination with oral administration of smectite powder, three time
Control group:The patient received intravenous administration of snake venom thrombin, twice daily, 1 unit each time, for 72 hours.
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 70 years old 2. Colorectal polyps, treated by endoscopic methods; 3. Fresh red bloody stool; 4. Preoperative hemoglobin stable, postoperative hemoglobin decreased by more than 3g/dL compared to preoperative level; 5. Good patient compliance, able to accept long-term follow-up; 6. No coagulation dysfunction, no history of mental illness; 7. No severe underlying diseases such as heart or lung conditions, able to tolerate anesthesia and surgery.
Exclusion criteria
Exclusion criteria: 1. Severe bleeding volume (>1000ml), with occurrence of hemorrhagic shock (blood pressure < 90/60mmHg) and other conditions; 2. Occurrence of perforation, infection and other situations; 3. Bleeding caused by other reasons such as hemorrhoids, diverticula, vascular malformations, etc.; 4. Allergic to montmorillonite and snake venom thrombin; 5. History of colorectal tumors, undergoing radiotherapy and chemotherapy; 6. Presence of severe organic diseases, coagulation dysfunction and other conditions that cannot tolerate surgery; 7. Patients who are unwilling to receive experimental treatment or cannot cooperate with follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 24-hour hemostasis rate after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of hematochezia;The amount of bleeding;Change in Hb level; | — |
Countries
China
Contacts
Public ContactLiu Li
The First Affiliated Hospital with Nanjing Medical University
Outcome results
None listed