Motor dysfunction of the limbs caused by non-progressive central nervous system injury in children
Conditions
Interventions
Upper limb control group:Conventional rehabilitation therapy combined with NMES treatment
Upper limb experimental group:Conventional rehabilitation therapy combined with BCI-FES treatment
Lower limb control group:Conventional rehabilitation therapy combined with NMES treatment
Lower limb experimental group:Conventional rehabilitation therapy combined with BCI-FES treatment
Sponsors
Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Age between 6 and 18 years, regardless of sex; 2.Diagnosed with non-progressive central nervous system injury of the brain, including but not limited to cerebral palsy and sequelae of traumatic brain injury; 3.Disease duration >= 1 month; 4.Presence of unilateral upper or lower limb motor dysfunction, with muscle strength of the wrist extensor or tibialis anterior < grade 3, and GMFCS level I–III for participants in the lower limb group; 5.Able to understand and follow instructions; 6.Written informed consent obtained from the child’s legal guardian.
Exclusion criteria
Exclusion criteria: 1.Presence of severe cognitive impairment, frequent epileptic seizures, or other conditions unsuitable for EEG recording; 2.Received botulinum toxin injection or orthopedic surgery within the past 6 months; 3.Implanted with devices sensitive to electrical stimulation, such as cardiac pacemakers or deep brain stimulation electrodes; 4.Currently participating in other interventional clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional assessment of the affected limb;Task-based fNIRS;Gait analysis in the lower limb group;Task-based EEG; | — |
Secondary
| Measure | Time frame |
|---|---|
| EEG training indicators;Safety evaluation;Physical examination of limb motor function; | — |
Countries
China
Contacts
Public ContactMin Shen
Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed