Parkinson's disease
Conditions
Interventions
Group M1:Repetitive transcranial magnetic stimulation treatment in area M1
Group PPC:Repetitive transcranial magnetic stimulation treatment in area PPC
Group M1+PPC:Repetitive transcranial magnetic stimulation treatment in area M1+PPC
The sham stimulation group:Fake stimulus action
Sponsors
The First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. It meets the revised diagnostic criteria for Parkinson's disease (PD) by the International Parkinson and Movement Disorder Society (MDS) in 2015, and is at Hoehn-Yahr (H-Y) stage 2-3. 2. There is a clear gait disorder, with a score of >= 2 points in the "gait" item of the Unified Parkinson's Disease Rating Scale (UPDRS) III, or a score of >= 3 points in the Simple Gait Analysis Scale (SGA). 3. The age ranges from 40 to 85 years old, with no gender restrictions, and is able to cooperate with rTMS treatment and data collection by wearable devices. 4. Voluntary signing of the informed consent form and approval by the hospital's ethics committee.
Exclusion criteria
Exclusion criteria: 1. There are contraindications for rTMS treatment, such as intracranial metallic implants (except for cochlear implants), a history of epilepsy, severe brain trauma or sequelae of stroke, and mental disorders (such as a depression score of =17 on the depression scale). 2. Patients with severe cardiopulmonary dysfunction, liver or kidney failure, or systemic diseases such as malignant tumors cannot tolerate the treatment and follow-up. 3. Gait disorders are caused by other diseases (such as lumbar spinal stenosis, arthritis, cerebellar lesions), rather than being caused by PD itself. 4. They cannot wear wearable devices (such as skin allergies, severe limitations in limb movement) or have cognitive impairments (Montreal Cognitive Assessment Scale MoCA score
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gait; | — |
Countries
China
Contacts
Public ContactYang Xinglong
The First Affiliated Hospital of Kunming Medical University
Outcome results
None listed