Aspiration
Conditions
Interventions
Ciprofol Group:For this study, it is administered as a single intravenous bolus dose of 0.3 mg/kg for induction during RSII.
Etomidate Group:For this study, it is administered as a single intravenous bolus dose of 0.3 mg/kg for induction during RSII.
Sponsors
ZhongShan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients undergoing general anesthesia requiring orotracheal intubation in the operating room; (2) Male or female, aged 18–80 years; (3) Presence of one or more risk factors for pulmonary aspiration: preoperative fasting time less than 6 hours; intestinal obstruction; history of vomiting within 12 hours before anesthesia; history of orthopedic trauma within 12 hours, severe symptomatic gastroesophageal reflux, hiatal hernia, gastroparesis, autonomic dysfunction, or gastroesophageal surgery with sphincter dysfunction; (4) ASA physical status I–III; (5) Voluntarily participate and provide signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Allergy to any medication used in the study; (2) Patients with an anticipated difficult airway; (3) Patients with preoperative hypoxemia (SpO2 < 90%) or shock (mean arterial pressure < 65 mmHg or requiring vasopressor support); (4) Pregnant patients; (5) Patients with preexisting aspiration before anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The first tracheal intubation was successful without any major complications.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intubation Conditions ;Induction Time;Intubation Time;Incidence of Severe Hypotension; | — |
Countries
China
Contacts
Public ContactChao Liang
ZhongShan Hospital Fudan University
Outcome results
None listed