Sepsis-associated encephalopathy
Conditions
Interventions
Sham stimulation group:Wear an ear stimulator, but do not give electrical stimulation
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for sepsis-associated encephalopathy and the onset time is no more than 48 hours. 2. Age >= 18 years old. 3. The patient or his/her legal representative voluntarily participates in the study and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Local skin infections, deformities, traumas or post-operative scars on the ear, which affect the attachment of the electrodes; 2. Those who have had internal implantation of electronic medical devices such as cardiac pacemakers or defibrillators (ICD); 3. Those with a history of vagus nerve section or a clear history of cervical vagus nerve injury; 4. Those with a history of bradyarrhythmia (such as sinus arrest, high-grade atrioventricular conduction block) or who have experienced severe cardiovascular adverse events; 5. Those with known underlying central nervous system diseases (such as stroke, dementia, Parkinson's disease, epilepsy, etc.); 6. Those who have had a history of head trauma or neurosurgery within the last 3 months; 7. Those with end-stage diseases (expected survival time < 72 hours) or those receiving palliative treatment; 8. Those who are extremely agitated, have continuous epileptic seizures or are unable to maintain a resting state, which affects the implementation and evaluation of the intervention; 9. Pregnant women or lactating women; 10. Those who are participating in other intervention research clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Protein S100 beta;Immunosuppressive molecules (CD4, CD8, regulatory T cells, etc.); | — |
Secondary
| Measure | Time frame |
|---|---|
| 12 T-cell factors;Glasgow Coma Scale;Acute Physiology and Chronic Health Evaluation System;Sequential Organ Failure Assessment;Other inflammatory indicators ( PCT, etc.);Duration of mechanical ventilation; | — |
Countries
China
Contacts
Public ContactZhang Linna
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed