Diabetic nephropathy
Conditions
Interventions
Control group:Receive the standard Western medicine treatment plan, including regular management of blood sugar, blood pressure and blood lipids: Hypoglycemic treatment: Metformin Hydrochloride (Appro
Experimental group:On the basis of this standardized background treatment, the patients in the observation group were given Dihuangye total glycoside capsule (National Medicine Zhunzi Z20070051, Sichu
Sponsors
Tangshan Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Western medicine diagnostic criteria: Refer to the diagnostic criteria for diabetic nephropathy in the "Diagnosis Criteria for Diabetic Nephropathy (2010)": Fasting blood glucose >= 7.0 mmol/L or 2-hour post-meal blood glucose >= 11.1 mmol/L), and meet any of the following conditions: Persistent microalbuminuria: Urinary albumin excretion rate (UAER) is in the range of 20-200 µg/min (or urinary albumin/muscle creatinine ratio is 30-300 mg/g), and positive results are obtained from repeated tests within at least 3 months; Manifest proteinuria: 24-hour urine protein total > 500 mg; Renal function impairment: Elevated serum creatinine (SCr) accompanied by decreased glomerular filtration rate (eGFR). Traditional Chinese medicine diagnostic criteria: Main symptoms: Edema; Urinary turbidity; Weakness and soreness in the waist and knees; Fatigue and weakness. Secondary symptoms: Dry mouth and throat; Cold limbs; Frequent nocturnal urination; Dark complexion. The patient must meet all the main symptoms and any 2 of the secondary symptoms, and the above-mentioned changes in tongue coating and tongue texture can be used for diagnosis. Inclusion criteria: Meet the aforementioned Western medicine and traditional Chinese medicine diagnostic criteria; Diabetes history >= 5 years; 24-hour urine protein quantification > 0.5 g; Organ functions: No obvious abnormalities in major organs such as the heart, liver, and kidneys.
Exclusion criteria
Exclusion criteria: Patients with high filtration stage nephropathy; Complicated with acute cardiovascular and cerebrovascular events or malignant tumors; Those who have a history of allergy to the study drugs; Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy rating;Renal function index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabonomics research methods; | — |
Countries
China
Contacts
Public ContactZhang Guojiang
Tangshan Hospital of Traditional Chinese Medicine
Outcome results
None listed