Nocturnal Hypertension
Conditions
Interventions
AB group:Phase 1: Receive Intervention A (Zopiclone 1mg on the right, ABPM sleep monitoring)
Washout period: -2 days (natural state, avoid using sedatives)
Phase 2: Receive Intervention B (ABPM sleep monitoring, placebo)
BA group:Stage 1: Receive Intervention B (ABPM, sleep monitoring, placebo)
Washout period: 2 days (natural state, avoid using sedatives)
Stage 2: Receive Intervention A (right-side Zopiclone 1mg, ABPM, sleep monitoring)
Sponsors
Daping Hospital, Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Nighttime blood pressure >= 120/70 mmHg on 24-hour ambulatory blood pressure monitoring; 3. Able to independently complete ABPM and PSG monitoring, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe insomnia (PSQI >16) or long-term use of benzodiazepines/sedatives; 2. Sleep apnea requiring CPAP; 3. Secondary hypertension (e.g., renal artery stenosis, primary aldosteronism, etc.); 4. Thyroid dysfunction (TSH exceeding twice the normal range); 5. Acute cardiovascular or cerebrovascular events (myocardial infarction, stroke, or unstable angina within the past 6 months); 6. Severe heart failure (NYHA class III-IV) or arrhythmia; 7. Acute exacerbation of chronic obstructive pulmonary disease, decompensated respiratory failure, or myasthenia gravis patients; 8. Active hepatitis or significant liver dysfunction (ALT or AST >2 ULN, TBIL >2 ULN, or Child-Pugh score >= class B); 9. Renal impairment (eGFR =3 time zones in the past month; 15. Pregnant or breastfeeding women; 16. Severe psychiatric disorders (PHQ-9 >=15) or cognitive impairment (MMSE <24); 17. Participants who have received other investigational drugs or medical device treatments within the month prior to screening or within 5 half-lives (whichever is longer).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ambulatory Blood Pressure Monitoring;Polysomnography; | — |
Countries
China
Contacts
Public ContactChunyu Zeng
Department of Cardiology, Daping Hospital, Army Medical University, Chongqing, P.R. China.
Outcome results
None listed