Acute ST-elevation myocardial infarction
Conditions
Interventions
Cool Oxygen inhalation group:Wear an oxygen mask daily to inhale cool (16°C) oxygen for 8 hours, continuing for one week.
Room-temperature oxygen inhalation group:Wear an oxygen mask daily to inhale room-temperature oxygen for 8 hours, continuing for one week.
Sponsors
The First Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) >=18 years of age; (2) Onset of symptoms (initial chest pain or tightness) =2 leads (>=0.1 mV in limb leads, >=0.2 mV in precordial leads V1-V3); (4) Pre-PCI TIMI flow grade =2 in the culprit vessel demonstrated by immediate post-PCI coronary angiography).
Exclusion criteria
Exclusion criteria: (1) Cardiac arrest or ventricular fibrillation before or after admission; (2) Uncontrolled acute left ventricular failure or pulmonary oedema; (3) Severe cardiogenic shock unresponsive to vasopressors; (4) Left main coronary artery disease or multivessel coronary artery disease (>=70% stenosis in at least two coronary arteries with diameter >=2.5mm); (5) History of myocardial infarction or coronary artery bypass grafting (CABG); (6) Severe valvular disease requiring surgical intervention; (7) Hypertrophic/restrictive cardiomyopathy; (8) Renal failure (eGFR <30 mL/min or requiring dialysis); (9) Hepatic failure (Child-Pugh Class C) or active hepatitis; (10) Severe respiratory disease (e.g., asthma, COPD, pulmonary embolism); (11) Malignant neoplasms or life expectancy <1 year; (12) Pregnant or lactating women; (13) Inability to participate in the study: dementia, psychiatric disorders, or inability to sign informed consent; (14) Concurrent participation in other interventional clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of major adverse cardiovascular and cerebrovascular events;Severe complications of ST-segment elevation myocardial infarction;cardiac function;Infarct area;NT-proBNP;hs-cTnI;CK-MB;hs-CRP;Indicators of ventricular systolic and diastolic function;Wall Motion Score Index;Arrhythmia events;Heart rate variability;Fecal metagenomic testing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Whole-blood single-cell sequencing;Plasma metabolomics testing;Oral metagenomic testing; | — |
Countries
China
Contacts
Public ContactYue Li
The First Affiliated Hospital of Harbin Medical University
Outcome results
None listed