Acute hypoxemic respiratory failure,AHRF
Conditions
Interventions
Observational group:None
Sponsors
The First Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients who have undergone or are expected to require invasive mechanical ventilation within 6h; 2. Age >=18 years; 3. Arterial blood gas analysis within 6h of admission to the ICU to meet the arterial partial pressure of oxygen (PaO2):inspired oxygen concentration (FiO2) ratio <300; 4. Indwelling arterial blood pressure monitoring and central venous catheter (internal jugular vein or subclavian vein catheter);
Exclusion criteria
Exclusion criteria: 1. Age <18 years old; 2. Pregnant and lactating women; 3. Expected to stay in the ICU for <=24h; 4. Thoracic deformities and any contraindications to the use of EIT (automated implantable cardioverter-defibrillator, thoracic wounds limiting electrode band placement, implantable pumps, etc.); 5. Patients with iodine contrast allergy; 6. Patients with contraindications to indwelling arterial blood pressure monitoring and central venous catheterization; patients with contraindications to placement of right median elbow vein indwelling needle; 7. Patients with severe thyroid disorders (hyperthyroidism); 8. Patients who had undergone cardiopulmonary resuscitation before the study, those with advanced malignant tumors, terminal stages of other diseases, or those who were considered by the clinician to be dying within 48h.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Three tools were used to evaluate the regional proportion thresholds of ventilation and blood flow matching (Shunt, Deadspace, GBR > 1, GBR < 1, NSND) for each type of AHRF; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient ICU length of stay;Duration of mechanical ventilation;ICU Survival or not;Survival of hospitalization;28 days of survival or not;Mechanical ventilation parameters before and after patient treatment;APACHE II and Sofa Ratings;Hemoglobin;D-dimer;Ultrasensitive C-reactive protein;Calcitonin;Arterial blood gas analysis; | — |
Countries
China
Contacts
Public ContactZheng Xia
The First Affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed