Pulmonary Tuberculosis
Conditions
Interventions
Experimental group:Use canagliflozin to lower blood sugar
Control group:Use other hypoglycemic drugs
Sponsors
Tongji University Affiliated Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Subject age: 18 years old <= age <= 75 years old, both male and female are eligible; 2. Subject weight: 40 kg <= weight <= 90 kg; 3. Patients with newly diagnosed, drug-sensitive pulmonary tuberculosis combined with type 2 diabetes; 4. HIV test negative; 5. Non-pregnant and non-lactating women, agree to continue using contraception throughout the study; 6. Fully understand the purpose and requirements of this trial and voluntarily sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. HIV-positive patients; 2. Patients with sputum culture indicating non-tuberculous mycobacteria (NTM); 3. Confirmed hepatobiliary diseases, including but not limited to chronic active hepatitis and/or liver dysfunction, HBsAg positive with high viral load (Hepatitis B e antigen positive), AST or ALT >3 times the upper limit of normal, TBIL >2 times the upper limit of normal; 4. The following history of kidney disease or kidney-related manifestations: unstable or rapidly progressive kidney disease; moderate/severe renal impairment or end-stage renal disease (eGFR = 133 µmol/L; female Cr >= 124 µmol/L).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| conversion rate of sputum culture;Cure rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in blood inflammatory markers; | — |
Countries
China
Contacts
Public ContactSha Wei
Tongji University Affiliated Shanghai Pulmonary Hospital
Outcome results
None listed