Thyroid Surgery
Conditions
Interventions
Esketamine group:Administer 0.3 mg/kg of esketamine during the induction of anesthesia.
Control group:As a control, an equivalent volume of normal saline is given at the time of preoperative induction.
Sponsors
The First Affiliated Hospital of Henan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65 years, with an American Society of Anesthesiologists (ASA) physical status classification of I to III; 2.Scheduled to undergo elective unilateral or bilateral thyroidectomy; 3.Body mass index (BMI) ranging from 18 to 30 kg/m^2; 4.Provision of signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Severe sleep apnea syndrome (diagnosed or highly suspected). 2.Severe cardiac, pulmonary, hepatic, or renal dysfunction. 3.History of psychiatric or neurological disorders, epilepsy, or substance abuse. 4.Known allergy to ketamine or any other medication used in this study. 5.Pregnancy or lactation. 6.Chronic use of sedative-hypnotics, antidepressants, or opioid analgesics. 7.preoperative insomnia (can be screened using the Pittsburgh Sleep Quality Index PSQI score > 7).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Athens Insomnia Scale;Time from End of Surgery to Extubation;Postoperative Agitation Score;Postoperative Adverse Reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep Quality;Heart Rate Variability;Quality of Recovery-15 Score;Hospital Anxiety and Depression Scale Score;Pittsburgh Sleep Quality Index;Visual Analogue Scale;Numerical Rating Scale;Post-Anesthesia Care Unit Length of Stay; | — |
Countries
China
Contacts
Public ContactJunjie Song
The First Affiliated Hospital of Henan University
Outcome results
None listed