A Study on the Role of Vitamin K2 in Brain Injury Among Preterm Infants via the Microbe-Gut-Brain Axis: A Multicentre Prospective Cohort Study

Status

Active, not recruiting

Phases

Phase 3

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600118433

Enrollment

Unknown

Registered

2026-02-05

Start date

2026-02-10

Completion date

Unknown

Last updated

2026-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perinatal white matter injury in preterm infants

Interventions

Vitamin K2 Normal Group:None

Vitamin K2 deficiency group:None

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Preterm infants with a gestational age of less than 37 weeks; Serum vitamin K2 level testing completed within 7 days of birth; Parents sign an informed consent form.

Exclusion criteria

Exclusion criteria: Major congenital malformations or chromosomal abnormalities; severe perinatal complications (such as severe intraventricular haemorrhage); children for whom follow-up is difficult to complete.

Design outcomes

Primary

Measure	Time frame
MRI+DTI/Cranial ultrasound;Faecal Microbiome and Metabolite Analysis;Vitamin K2 concentration;Bayley Scales of Infant Development;Inflammatory mediators;	—

Countries

China

Contacts

Public ContactHongmei Tang

Guangzhou Medical University Affiliated Women and Children's Medical Centre

gdthm@126.com+86 189 2752 3984

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 15, 2026