Spinal Muscular Atrophy type ?
Conditions
Interventions
Experimental Group:Trunk Control Exercise
Control Group:Home-based Guidance
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
3 Years to 17 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for SMA Study Participants: Participants must (1) be diagnosed with SMA type II by a neurologist and confirmed through genetic testing; (2) be aged 3–17 years and score =27 on the Mini-Mental State Examination (MMSE) to ensure adequate cognitive ability to comprehend and cooperate with the study; (3) demonstrate the ability to maintain sitting balance independently or with minimal assistance (meeting Bobath Sitting Balance Grade I or lower); (4) be receiving ongoing treatment with Nusinersen to maintain consistency in clinical management; (5) attend outpatient physical therapy sessions at least three times per week; and (6) provide written informed consent from either the participant or their legal guardian following full comprehension of the study details.
Exclusion criteria
Exclusion criteria: Participants will be excluded if they: (1) have previously undergone spinal surgery requiring extended bedside care; (2) are currently enrolled in other SMA-related rehabilitation programs at hospitals, clinics, or rehabilitation centers; (3) present with conditions unsuitable for rehabilitation exercises, such as pain during movement, post-exercise injuries, or strains; (4) are unable to provide informed consent, either personally or through a legal guardian; (5) can only attend fewer than five therapy sessions per week for any reason; or (6) are unable to complete the study due to fatigue or muscle weakness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional near-infrared brain imaging status, fNIRS;Surface electromyographic (sEMG) activation status of the targeted muscle group(s); | — |
Secondary
| Measure | Time frame |
|---|---|
| Hammersmith functional motor scale Expanded,HFMSE;ratings of perceived exertion,RPE;Pediatric Quality of Life Inventory Multi Dimensional Fatigue Score,PedsQLMFS; | — |
Countries
China
Contacts
Public ContactZhang Jing
West China Hospital of Sichuan University
Outcome results
None listed