Sepsis-Associated Acute Kidney Injury
Conditions
Interventions
Gold Standard:The 2012 KDIGO guidelines for the diagnosis of AKI (meeting any of the following criteria): an increase in serum creatinine (Scr) of =0.3 mg/dL (26.5 µmol/L) within 48 hours
an increase in serum creatinine to =1.5 times baseline, with the above changes known or presumed to have occurred within 7 days
urine output <0.5 mL/kg/h for more than 6 hours.
Index test:Neutrophil Gelatinase-Associated Lipocalin and D-dimer
Sponsors
The Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years old; 2.Sepsis is diagnosed in accordance with the Sepsis 3.0 diagnostic criteria: there is confirmed or suspected infection, and the Sequential Organ Failure Assessment (SOFA) score is >= 2 points. 3. The definition of AKI includes an increase in SCr of >=0.3 mg/dl (>=26.5 µmol/l) within 48 hours, an increase in SCr to >=1.5 times the baseline within the past 7 days, or urine output <0.5 ml/kg/h for 6 hours.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of chronic renal insufficiency; 2.Patients who have developed AKI at the time of admission. 3.Patients who have undergone renal surgery, have renal vascular abnormalities, or have received a kidney transplant; 4.Patients with increased intra-abdominal pressure (intra-abdominal pressure =12 mmHg). 5.Patients with urinary tract infections. 6.Pregnant or lactating women. 7.Patients who refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biomarkers for the Assessment of Coagulation Dysfunction in Sepsis Patients.;Urine output < 0.5 mL/kg/h for =6 hours is a criterion for AKI;Designed for the early diagnosis of AKI in sepsis patients;Designed for the early diagnosis of AKI;Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactLiangbin Hu
The Affiliated Hospital of Southwest Medical University
Outcome results
None listed