Post-stroke Depression
Conditions
Interventions
Experimental group:Individualized tDCS, stimulation target, current intensity, electrode configuration, etc. are customized individually, and verified by fNIRS before each treatment to ensure effectiv
Control Group:The general clinical standardization scheme was adopted: the electrode configuration was F3 point on the left side of the anode (International 10-20 system), the shoulder peak on the rig
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Meeting the diagnostic criteria of *Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke in China 2022* (first-episode ischemic/hemorrhagic stroke), with onset time of 3-6 months; 2.Meeting the diagnostic criteria for depressive disorder in DSM-5, with a Hamilton Depression Rating Scale (HAMD-17) score >= 17; 3.Being able to cooperate with fNIRS detection and tDCS treatment, with expected follow-up compliance >= 80%; 4.Signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Comorbid with other major mental disorders such as bipolar affective disorder and schizophrenia; 2.Severe cognitive impairment (score of Mini-Mental State Examination (MMSE) < 24); 3. Contraindications to tDCS such as intracranial metal implants (e.g., cardiac pacemaker, cochlear implant) and history of epilepsy; 4.Adjustment of antidepressant dosage or addition of new psychotherapy in the past month; 5.Severe underlying diseases such as severe hepatic, renal or cardiac insufficiency, and malignant tumor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Hamilton Depression Scale Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montgomery Depression Scale Score;Hamilton Anxiety Scale Score;National Institute of Health stroke scale Score;Modified Barthel Index;Changes in core fNIRS indicators;Changes in Quality of Life Scores (SF-36 Scale); | — |
Countries
China
Contacts
Public ContactWeiming Sun
The First Affiliated Hospital of Nanchang University
Outcome results
None listed