Sarcopenia
Conditions
Interventions
Sarcopenia Group:None
Retrospective data group (extracting standard-compliant cranial MRI/CT and chest CT image data from the electronic medical record system:None
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Prospective Cohort Study: Scheduled to undergo orthopedic surgery (e.g., tumor resection, fracture repair, etc.); Capable of completing diagnostic assessments for sarcopenia (including calf circumference, handgrip strength, and skeletal muscle mass measurements); Has provided signed informed consent. 2.Retrospective Cross-sectional Study: Possesses complete cranial or thoracic imaging data; Has lipid profile, biochemical test results, and relevant clinical data.
Exclusion criteria
Exclusion criteria: 1.Prospective Cohort Study: Advanced malignant tumor with cachexia; Severe hepatic or renal dysfunction (e.g., eGFR <15 mL/min/1.73m^2); Acute infection or inflammatory state; Inability to cooperate with follow-up. 2.Retrospective Cross-sectional Study: History of acute cranial trauma, intracranial infection, or intracranial neoplasms (including primary and metastatic tumors); Unavailable or incomplete imaging data; Lack of essential clinical data (including lipid profiles, medical history, and demographic details).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical diagnosis and imaging features of sarcopenia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Deterioration of muscle function (incidence of falls and fractures;Neurodegenerative markers (such as white matter hypersignaling);Exposure factors: APOE genotype (e2/e3/e4), HCN1 protein expression level; | — |
Countries
China
Contacts
Public ContactLiu Jiantao
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed