Sepsis
Conditions
Interventions
Healthy Control Group:None
Sponsors
Hangzhou First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Sepsis patient group: (1) Diagnostic criteria: Meet the diagnostic criteria for sepsis or septic shock in the Third International Consensus Definitions for Sepsis and Septic Shock; (2) Age range: 18 years = age = 75 years; (3) Time of onset: Enrollment within 48 hours after sepsis diagnosis; (4) Informed consent: Written informed consent voluntarily signed by the patient or their legally authorized representative; 2. Healthy control group: (1) Health status: No acute or chronic infectious diseases, autoimmune diseases, active malignancies, or severe liver, kidney, or hematological disorders based on health questionnaire and routine physical examination; (2) Age and gender matching: Age matched to the case group (±5 years), with similar gender distribution; (3) Informed consent: Written informed consent voluntarily signed by the volunteer.
Exclusion criteria
Exclusion criteria: 1. Patients with major underlying diseases: Those with severe cirrhosis (Child-Pugh Class C), end-stage renal disease (on dialysis), New York Heart Association (NYHA) heart failure class IV, confirmed hematologic malignancies, post-solid organ or hematopoietic stem cell transplantation, or requiring long-term immunosuppressive therapy. 2. Patients with special infectious status: Those with a confirmed diagnosis of human immunodeficiency virus (HIV) infection or active tuberculosis. 3. Patients with special physiological or pathological conditions: Pregnant or lactating women. 4. Patients with limitations on study sample collection: Those with difficulty establishing venous access or severe coagulopathy leading to inability to obtain sufficient qualified blood samples. 5. Other circumstances that may interfere with study results: Patients who received leukocyte-containing blood products within 24 hours prior to enrollment; any other condition deemed by the investigator to potentially affect immune function assessment or expose the subject to unacceptable risk.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality rate;SOFA score;APACHE II Score;Levels of inflammatory factors (such as IL-6, PCT;Organ function indicators; | — |
Countries
China
Contacts
Public ContactWang Hanbin; Zhang Weiyan
Hangzhou First People's Hospital
Outcome results
None listed