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A prospective cohort study on the effects of Akkermansia muciniphila and its metabolite pentadecanoic acid on liver regeneration after hepatectomy

A prospective cohort study on the effects of Akkermansia muciniphila and its metabolite pentadecanoic acid on liver regeneration after hepatectomy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600118402
Enrollment
Unknown
Registered
2026-02-05
Start date
2026-02-15
Completion date
Unknown
Last updated
2026-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma

Interventions

Observation group:None

Sponsors

West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Patients in generally good condition; 2.American Society of Anesthesiologists (ASA) physical status classification of I/II; 3.Preoperative liver function assessed as Child-Pugh class A; 4.Indocyanine green retention rate at 15 minutes (ICG R15) =3 liver segments; 6.Negative surgical margin.

Exclusion criteria

Exclusion criteria: 1.Presence of severe liver cirrhosis or steatohepatitis; 2.Use of anti-inflammatory medications within 2 weeks prior to surgery; 3.Postoperative receipt of chemotherapy, targeted therapy, or immunotherapy; 4.Recurrent hepatocellular carcinoma requiring a second or multiple hepatectomies; 5.Concurrent resection of other organs; 6.History of other malignancies.

Design outcomes

Primary

MeasureTime frame
Liver regeneration rate;

Secondary

MeasureTime frame
Regenerated liver volume;Regenerated liver volume;Liver regeneration rate;

Countries

China

Contacts

Public ContactZeng Yong

West China Hospital of Sichuan University

Zengyong@medmail.com.cn+86 28 85422114

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 15, 2026