Acute Postoperative Pain After Minimally Invasive Off-Pump Coronary Artery Bypass Grafting
Conditions
Interventions
Experimental Group:Single liposomal bupivacaine Group
Active Comparator Group:Continuous bupivacaine hydrochloride group
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Scheduled for elective minimally invasive cardiac surgery–coronary artery bypass grafting via a left anterolateral mini-thoracotomy;
Exclusion criteria
Exclusion criteria: 1.Contraindications to nerve block, including coagulopathy, local infection at the puncture site, thoracic spinal deformity, or history of thoracic spine surgery. 2.Inability to cooperate with nerve block procedures (e.g., patients with impaired consciousness or severe psychiatric disorders). 3.Hypersensitivity to ultrasound coupling agents, local anesthetics (e.g., bupivacaine, ropivacaine), or opioids. 4.History of chronic pain (defined as persistent or recurrent pain >= 3 months), including chronic pain resulting from previous surgery, trauma, or other diseases, or long-term use of oral analgesics. 5.Inability to comprehend pain assessment scales or operate patient-controlled analgesia devices. 6.Pregnancy or lactation. 7.History of coronary artery bypass grafting. 8.Participation in another clinical trial or refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve of cumulative resting pain scores within 72 hours after tracheal extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative observation indicators;Immediate complications;Postoperative delirium;Total opioid consumption within 72 hours postoperatively (converted to morphine milligram equivalents, MME);Area under the curve of cumulative resting pain scores within 72 hours after tracheal extubation;Postoperative recovery quality, Sleep quality, Postoperative Sedation Levels;The duration of the nerve block catheterization procedure;Long-term outcomes;Postoperative cardiac biomarkers and cardiovascular complications;Analgesia satisfaction;Postoperative respiratory function and respiratory complications;Adverse events;Immediate NRS score at puncture,Satisfaction with the puncture procedure;Anxiety and depressive states;Early postoperative recovery outcomes;The depth of the nerve block catheter placement; | — |
Countries
China
Contacts
Public ContactMin Li
Peking University Third Hospital
Outcome results
None listed