Chronic hepatitis B
Conditions
Interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. HBsAg positive and HBeAg negative; 2. All participants had not used interferon antiviral therapy before enrollment; 3. The diagnosis met the diagnostic criteria of the 2022 revised Guidelines for the prevention and treatment of chronic hepatitis B; 4. Voluntarily cooperate to complete the follow-up.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or planned pregnancy in the near future; 2. Underlying diseases such as psychiatric history (schizophrenia or severe depression), uncontrolled epilepsy, unabstinent alcohol/drug addict, uncontrolled autoimmune disease, decompensated liver cirrhosis, thyroid disease, severe infection, retinal disease, heart failure, chronic obstructive pneumonia, etc.; 3. Neutrophil count < 1.0×10^9/L and platelet count < 50×10^9/L before treatment. (Note: Ultrasound or CT is used to rule out cirrhosis.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral blood CD4+PD-1+T level;Peripheral blood CD8+PD-1+T level;Serum HBsAg levels;Serum HBV DNA levels;Serum HBV RNA levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Albumin;Bilirubin;Alpha-fetoprotein;Self-Rating Depression Scale (SDS);Liver ultrasound for monitoring cirrhosis;Number and size of hepatic nodules;APRI (AST-to-Platelet Ratio Index);FIB-4 (Fibrosis-4 Index);GPR (Gamma-Glutamyl Transferase-to-Platelet Ratio); | — |
Countries
China
Contacts
Public ContactEnqiang Chen
West China Hospital, Sichuan University
Outcome results
None listed