Postoperative pain
Conditions
Interventions
Control Group:Add the same volume of normal saline to the PCA formula, dilute to 120ml at a rate of 2.5ml/h, with a single booster dose of 2mL, and lock the time for 15 minutes
Esmolol Group:Add 14.4mg/kg esmolol to the PCA formula, dilute to 120ml at a rate of 2.5ml/h, with a single booster dose of 2mL, and lock time for 15 minutes
Sponsors
Wuxi people’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA levels I-IV; 2. Basic heart rate >= 60 beats per minute; 3. Gastrointestinal surgery under general anesthesia; 4. Age range: 18-65 years old;
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Body Mass Index (BMI) >= 35 kg/m^2; 3. Diabetes; 4. Allergies to drugs under study; 5. Contraindications related to esmolol; 6. Severe liver and kidney dysfunction (child pugh c grade, renal replacement therapy); 7. Suffering from mental illness; 8. Recently used beta blockers; 9. Suffering from coronary heart disease and other cardiac abnormalities; 10. Unable to understand the numerical rating scale; 11. Unable to provide informed consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in postoperative pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin-1ß;Interleukin-6;Heart rate;Hypotension;Tumor necrosis factor-a;Bradycardia;Respiratory depression;Nausea and vomiting;Mean arterial pressure;Dizziness; | — |
Countries
China
Contacts
Public ContactQian Yiling
Wuxi people’s Hospital
Outcome results
None listed