paclitaxel-induced peripheral neuropathy
Conditions
Interventions
Control group:Standard care
HBOT group:hyperbaric oxygen therapy
Sponsors
Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.aged >= 18 years and = 4/10;
Exclusion criteria
Exclusion criteria: 1.Patients who have previously taken drugs that may affect the evaluation of Nab-PIPN symptoms, such as duloxetine, venlafaxine, gabapentin, pregabalin, and amitriptyline; 2.Patients with any other pathological conditions or diseases that could affect Nab-PIPN assessment, including alcoholic peripheral neuropathy, uremic peripheral neuropathy, diabetic peripheral neuropathy, thiamine deficiency-related peripheral neuropathy, and chronic axonal peripheral neuropathy of unknown etiology; 3.Patients who have contraindications for hyperbaric oxygen therapy, including pulmonary disorders (severe chronic obstructive pulmonary disease, bullous lung disease, acute or chronic pulmonary infection, uncontrolled asthma, untreated pneumothorax), history of previous middle ear surgery, middle ear diseases (eustachian tube dysfunction, recurrent vertigo), and ocular conditions (retinal detachment); 4.Karnofsky Performance Status score < 80; 5.Patients with any other conditions that the investigator deems unsuitable for participation in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EORTC QLQ-CIPN20 score; | — |
Secondary
| Measure | Time frame |
|---|---|
| NCI-CTCAE 5.0 score;Electromyogrphy indicators;EORTC QLQ-C30 scale score;BPI-SF score; | — |
Countries
China
Contacts
Public ContactKun Wang
Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)
Outcome results
None listed