Pancreatic cancer
Conditions
Interventions
Therapy group:Low-dose radiotherapy (2Gy per dose, once a week) combined with ptilimab (200mg, intravenous drip, every 3 weeks) and standard chemotherapy regimens (AG or FOLFIRINOX)
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-75 years old, gender not limited. 2. The ECOG score ranges from 0 to 1. 3. Patients with malignant pancreatic tumors confirmed by histology or cytology; 4. Has not received previous treatment with PD-1 or PD-L1 inhibitors; 5. Have target lesions that can be radiotherapy-treated; 6. The subjects voluntarily joined this study and signed the informed consent form voluntarily.
Exclusion criteria
Exclusion criteria: 1. Has received radiotherapy in the past; 2. There are uncontrolled chronic infectious and non-infectious diseases, including but not limited to: heart failure that cannot be controlled by medication, hypertension that is difficult to control, etc. 3. Severe infections that are in the active stage or have poor clinical control; 4. Those with a history of abuse of psychotropic drugs and unable to quit, or patients with mental disorders; 5. Pregnant or lactating women, and patients with fertility who are unwilling or unable to take effective contraceptive measures; 6. The researcher judges other circumstances that may affect the progress of clinical research and the determination of research results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall Survival;Progression-free survival;Disease control rate; | — |
Countries
China
Contacts
Public ContactYang Liu
Zhejiang Provincial People's Hospital
Outcome results
None listed