Sepsis complicated with acute gastrointestinal injury
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.After admission to the ICU of our hospital, in accordance with the diagnostic criteria for sepsis in "The Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021 Edition" , the definition of sepsis 3.0 is that the body's response to infection becomes disordered, leading to life-threatening organ dysfunction. For patients with infection or suspected infection, when the Sequential Organ Failure Assessment score (SOFA) is >= 2 points, sepsis is considered to exist. Moreover, AGI grade II or above (reference to the AGI diagnostic criteria 4 formulated by the European Society of Intensive Care Medicine (ESICM)); 2. Age >= 18 years old; 3. The patient's family consents to participate in this study.
Exclusion criteria
Exclusion criteria: 1.The diagnostic criteria for the combination of severe thoracic and abdominal trauma; 2. Use of gastrointestinal motility-promoting drugs before enrollment; 3. Local skin damage at acupoints such as Zusanli, Zhongwan, Tianqiu, Shangguizhu, Sanyinjiao, Zhongwan, etc. is not suitable for electro-acupuncture; 4. Blood routine with platelet count 2.0); 5. Existing severe primary gastrointestinal diseases (such as massive gastrointestinal bleeding, mechanical intestinal obstruction, intestinal perforation); 6. Hemodynamic instability remained 24 hours after admission to ICU; 7. Extremely critical condition with rapid deterioration within 48 hours, expected to die within 48 hours; 8. Terminal stage of malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Diamine oxidase;Lipopolysaccharides;Motilin;Gastrointestinal failure score;Transforming growth factor-ß, TGF-ß;Interleukin-17, IL-17;Interleukin-10, IL-10;Interleukin-23, IL-23;Interleukin-6, IL-6;Human leukocyte DR Antigen, HLA-DR;The number of Th17 cells in peripheral blood;The number of treg cells in peripheral blood;Percentage of Th17/treg in peripheral blood;Albumin;Prealbumin;Acute physiology and chronic health evaluation ? score, APACHE? score;Sequential organ failure evaluation system score, SOFA;Duration of mechanical ventilation;Duration of ICU stay; | — |
Countries
China
Contacts
Public ContactXing Xi
The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine
Outcome results
None listed