hematopoietic stem cell transplantation
Conditions
Interventions
?~? acute graft·versus-host disease group:None
0~I acute graft·versus-host disease group:None
Normal control group:None
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
14 Years to 60 Years
Inclusion criteria
Inclusion criteria: Case group: 1. Age range from 14 to 60 years old, regardless of gender; 2. Patients with hematological disorders undergoing allogeneic hematopoietic stem cell transplantation; 3. The subjects voluntarily participate in the trial and sign the informed consent form, and the process of signing the informed consent form meets the requirements of GCP. Healthy controls: 1. Participants of both sexes, aged 14-60 years, who underwent physical examination during the same period; 2, no past medical history and genetic history, confirmed as a healthy person by physical examination.
Exclusion criteria
Exclusion criteria: Case group: 1. Individuals with severe cardiac insufficiency and a heart ejection fraction EF below 60%; or severe arrhythmia, or intolerant to strong preconditioning evaluated by researchers; 2. Patients with severe pulmonary insufficiency (obstructive and/or restrictive ventilation disorders) who cannot tolerate the preconditioning regimen as evaluated by the researchers; 3. Severe liver dysfunction accompanied by liver function indicators (ALT, TBIL) exceeding the upper limit of normal values (ULN) by more than 3 times; Researchers evaluate individuals who cannot tolerate strong preconditioning regimens; 4. Accompanied by severe renal insufficiency, the renal function index (Cr) is more than twice the upper limit of normal (ULN); or if the 24-hour urinary creatinine clearance rate (Ccr) is less than 50ml/min, and the researcher evaluates that they cannot tolerate the super strong pre-treatment regimen; 5. Severe active infection before transplantation, evaluated by researchers as unable to tolerate preconditioning beyond tolerance; 6. Individuals who have experienced allergic reactions or serious adverse reactions during previous use of preconditioning related drugs and have been evaluated as ineligible by the researchers; 7. Other reasons for not being included in the researcher's evaluation. 8. The researcher determined that the participants were not suitable for this experiment. Healthy controls: Exclusion criteria were those who were deemed by the investigators to be unfit for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bile acid of Intestinal metabolites;Cytokine;Mononuclear cells; | — |
Secondary
| Measure | Time frame |
|---|---|
| Microbiota;Biomarkers; | — |
Countries
China
Contacts
Public ContactLijie Han
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed