Effect of intravenous lidocaine on the response to insertion during painless gastroscopy
Conditions
Interventions
Lidocaine Group(L Group):Following routine monitoring, all patients received an intravenous injection of fentanyl 0.5 µg/kg (administered over a period of no less than 30 seconds). According to their
Saline control group (Group C):Following routine monitoring, all patients received an intravenous injection of fentanyl 0.5 µg/kg (administered over a period of no less than 30 seconds). According to
Sponsors
The First Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65 years; 2.Scheduled to undergo elective, diagnostic painless gastroscopy based on clinical needs; 3.American Society of Anesthesiologists (ASA) Physical Status Classification of I to III; 4.Body Mass Index (BMI) between 18 and 28 kg/m^2; 5.Voluntarily agrees to participate and provides signed informed consent; 6.Not concurrently participating in any other interventional clinical trial.
Exclusion criteria
Exclusion criteria: 1.Known allergy to lidocaine, fentanyl, propofol, soybeans, or eggs; 2.Severe cardiovascular diseases: sick sinus syndrome, high-degree atrioventricular block, unstable angina, severe heart failure, etc; 3.Severe respiratory diseases: severe chronic obstructive pulmonary disease (COPD), uncontrolled asthma, sleep apnea syndrome, etc; 4.Severe hepatic or renal insufficiency: Child-Pugh Class C; estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m^2; 5. Anticipated difficult airway or anatomical abnormalities that may complicate gastroscope insertion; 6.Long-term alcohol abuse or substance abuse; 7.Psychiatric or cognitive disorders impairing normal communication or cooperation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive rate of insertion response during gastroscopy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Propofol dosing (induction dose, total dose) ;Hemodynamic changes (heart rate and blood pressure measured before, during, and within 1 minute after insertion);Coughing and body movement;Respiratory Depression;Hypotension;PONV, dizziness and headache;Endoscopist satisfaction; | — |
Countries
China
Contacts
Public ContactLi Xin
The First Affiliated Hospital of Air Force Medical University
Outcome results
None listed