Severe preeclampsia
Conditions
Interventions
Trial group:HRV monitoring + routine sedation and analgesia
Control group:Conventional sedation and analgesia (without HRV monitoring)
Sponsors
Shijiazhuang Maternity Hospital/Shijiazhuang Fourth Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Patients with severe preeclampsia underwent cesarean section; 2. After the operation, they were transferred to the ICU for sedation and analgesia treatment; 3. Age range: 20-40 years old; 4. No history of severe heart or lung diseases, or neurological disorders; 5. Signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Failure to complete the research process: such as inability to cooperate in completing 5-minute HRV monitoring, etc. 2. Postpartum hemorrhage related to this pregnancy, severe infection; 3. History of severe complications: such as previous cases of amniotic fluid embolism, myocardial infarction, cerebrovascular events, etc. 4. Inability to communicate effectively or give informed consent: such as patients with mental disorders or those who cannot sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The additional dosage of flurbiprofen axetil and the incidence of adverse reactions.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory indicators (systemic immune inflammation index, interleukin-6, CRP);Comparison of differences in spectral analysis (low-frequency and high-frequency power) between the two groups;The preoperative heart rate variability between the two groups and the changes at 24 hours and 48 hours after the operation;Comparison of early renal injury indicators (neutrophil gelatinase-associated lipocalin) 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactWang Hong
Shijiazhuang Maternity Hospital/Shijiazhuang Fourth Hospital
Outcome results
None listed