Postoperative sore throat
Conditions
Interventions
Esketamine group (experimental group):Gargle with 30ml of mouthwash [50mg Esketamine (Jiangsu Hengrui, 2ml:50mg)+28ml normal saline] for 60s 5-10min before induction.
Control group:Gargle with 30ml of 30ml normal saline for 60s 5-10min before induction.
Sponsors
Longhua District Bureau of Health, Shenzhen
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old, 2. Elective thyroidectomy, 3. Patients with American Society of Anesthesiologists (ASA) grade I-III
Exclusion criteria
Exclusion criteria: 1. There was previously a sore throat and hoarseness of voice; 2. Patients who had taken NSAIDs or steroid drugs or calcium channel blockers before the surgery; 3. Those with recent or recurrent respiratory infections; 4. Patients with contraindications to esketamine; 5. Those with a history of intubation difficulties or a predicted difficult airway and postoperative aspiration; 6. Patients with reflux esophagitis; 7. Pregnant and lactating women; 8. Patients with morbid obesity [Body Mass Index (BMI) > 35 kg/m^2) ] and those with mental disorders who cannot cooperate will also be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative sore throat (%);Severity of sore throat (VAS score, 0-10 points); | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events within 48h after surgery(%);Quality of postoperative recovery (QoR-15 total score: 0-150 points); | — |
Countries
China
Contacts
Public ContactKuang Xin
Longhua People's Hospital, Shenzhen
Outcome results
None listed