Bone metastasis of breast cancer
Conditions
Interventions
Treatment group:The subjects were intervened with the postoperative formula for breast cancer and the formula for nourishing the kidney and regulating the liver. The ingredients of the kidney-Nourishi
Control group:Postoperative formula for breast cancer: Raw Astragalus membranaceus 15g, Codonopsis pilosula 12g, stir-fried Atractylodes macrocephala 9g, Poria cocos 12g, Astragalus umbellatus 30g, Co
Sponsors
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 and <=75 2. Diagnosed with breast cancer and concomitant bone metastases from breast cancer 3. TCM syndrome pattern consistent with "liver and kidney deficiency" 4. ECOG performance status = 3 5. Willing to accept the treatment protocol of this study
Exclusion criteria
Exclusion criteria: 1. Those with severe cardiovascular and cerebrovascular diseases, liver and kidney dysfunction, or hematological disorders. 2. Those with a history of other tumors. 3. Those with mental disorders who cannot cooperate with the trial. 4. Those who have participated in other clinical trials within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease control rate;Bone metabolism markers (osteocalcin, 25-hydroxyvitamin D, ß-collagen specific sequence, total type I collagen amino-terminal extension peptide determination);Bone density test;Expression of SOCS3 in peripheral blood and methylation level of SOCS3;Serum alkaline phosphatase (ALP) in peripheral blood, albumin-to-alkaline phosphatase ratio (AAPR), red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR) in peripheral blood, and carbohydrate antigen 15-3 (CA15-3);Traditional Chinese Medicine symptom and sign scoring;Pain assessment;Quality of Life Assessment; | — |
Countries
China
Contacts
Public ContactChen Hongfeng
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Outcome results
None listed