Patients with cerebral small vessel disease, and MRI imaging shows typical manifestations of cerebral small vessel disease, such as white matter hyperintensities, lacunar infarcts, cerebral microbleeds, and enlarged perivascular spaces.
Conditions
Interventions
Case group:None
Sponsors
Shanxi Cardiovascular Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged 18 years or older. 2.Clinically diagnosed with cerebral small vessel disease, and MRI imaging shows typical manifestations of cerebral small vessel disease, such as white matter hyperintensities, lacunar infarcts, cerebral microbleeds, and enlarged perivascular spaces. 3.Willing to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Within 3 months of the onset of an acute cerebrovascular event. 2. Patients with severe stroke and previous brain disease, neurological infections, head trauma, demyelinating diseases, neurodegenerative diseases and brain tumours, such as Alzheimer's disease and Parkinson's disease. 3. with severe systemic diseases such as heart failure, liver and renal insufficiency. 4. have used medications within the last 3 months that may affect inflammatory factor levels or cognitive function. 5. the presence of mental illness or cognitive dysfunction that would interfere with study co-operation. 6. subjects with life expectancy = 5 years due to advanced cancer and other diseases. 7. contraindications to MRI examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive assessment;Total Burden Score of Imaging for Cerebral Small Vessel Disease; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ambulatory Blood Pressure Monitoring;Levels of inflammatory markers; | — |
Countries
China
Contacts
Public ContactWeirongLee
Shanxi Cardiovascular Hospital
Outcome results
None listed