Infertility
Conditions
Interventions
Experimental group:The DNA/RNA multi-omics predictive model predicts and scores euploid embryos for ongoing pregnancy success, prioritizing higher-scoring embryos for transfer.
Control group:Euploid embryo transfer by standard PGT-A selection
Sponsors
Reproductive Medicine Center, Shanxi Provincial Maternal and Child Health Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. For patients undergoing PGT-A treatment, the indications for PGT-A treatment include advanced maternal age (>= 35 years old), or/and two or more recurrent spontaneous abortions of unknown cause, or/and repeated implantation failures (transplantation >= 3 times and at least 3 high-quality embryos failed to result in clinical pregnancy). 2.At least 2 euploid blastocysts, and morphological rating (4BC/4CB or above) 3.Voluntary participation in this study and signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with uterine cavity abnormalities, such as congenital uterine malformations (unicornuate, bicornuate or didelphic uterus); untreated uterine septum, submucosal fibroids or endometrial polyps; or history of moderate to severe intrauterine adhesions. 2.Severe hydrosalpinx with tubal fluid reflux into uterine cavity that remains untreated. 3.Patients planning to undergo PGT-SR (preimplantation genetic testing for structural rearrangements) or PGT-M (preimplantation genetic testing for monogenic disorders) or sex selection due to Y chromosome microdeletion. 4.Patients using donor sperm or donor eggs to achieve pregnancy. 5.Untreated severe medical or surgical conditions. 6.Vulnerable populations, including individuals with mental illness, cognitive impairment, critically ill patients, minors, pregnant women, etc. 7.Other conditions that the investigator deems unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate;Early miscarriage rate; | — |
Countries
China
Contacts
Public ContactXueqing Wu
Reproductive Medicine Center, Shanxi Provincial Maternal and Child Health Hospital
Outcome results
None listed