Hip Fracture Surgery
Conditions
Interventions
DE group:Esketamine was administered intravenously during anesthesia induction, while dexmedetomidine was infused through the postoperative patient-controlled analgesia pump.
C group:An equal volume of normal saline was used in place of both esketamine and dexmedetomidine.
Sponsors
Xishan People’s Hospital of Wuxi City
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: age>=65 years, American Society of Anesthesiologists (ASA) physical status II–III, scheduled for elective hip fracture surgery, and a preoperative Athens Insomnia Scale (AIS) score >6.
Exclusion criteria
Exclusion criteria: A history of preoperative delirium; preexisting cognitive impairment as determined by the Mini-Mental State Examination (MMSE) (illiterate =17, primary school =20, secondary school or above =24); severe arrhythmia, bradycardia (heart rate <50 beats/min), or atrioventricular block; severe hepatic or renal dysfunction; a history of psychiatric disorders; language or sensory impairment precluding assessment; and known allergy or contraindications to the study medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium within the first 3 postoperative days; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative sleep quality on the first and second postoperative nights;Numeric Rating Scale pain scores at rest and during movement at 1, 3, 6, 12, 24, and 48 h after surgery;cumulative sufentanil consumption during the intervals 0–12 h, 12–24 h, 0–24 h, 24–48 h, and 0–48 h postoperatively; | — |
Countries
China
Contacts
Public ContactQingren Liu
Xishan People’s Hospital of Wuxi City
Outcome results
None listed