Hypertension
Conditions
Interventions
Group of patients with hypertension:N/A
Group of patients with normal blood pressure:N/A
Group of conventional intervention:Receive routine standardized health guidance provided by community doctors through face-to-face consultations once every three months.
Group of digital reinforcement intervention:In addition to routine guidance, individualized behavioral interventions are implemented through a digital platform
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Construction and follow-up of a community-based prospective cohort Hypertension group: (1) confirmed diagnosis of essential hypertension (previous diagnosis certificate or long-term medication record in community outpatient clinic could be provided); (2) or taking antihypertensive drugs; (3) or blood pressure >=140/90 mmHg measured on three different days without medication. Control group: (1) no history of hypertension; (2) not taking any antihypertensive drugs; (3) Measured blood pressure was stable = 45 years old and permanent community residents; (3) agreed to accept behavioral intervention and follow-up; (4) Mobile phones or family members can assist and supervise. 3. Mechanism research: omics analysis of blood markers: (1) qualified biological samples were collected and cryopreserved; (2) complete and representative screening data; (3) Clear blood pressure stratification, which can cover normal, prehypertension and hypertension stages.
Exclusion criteria
Exclusion criteria: 1. Construction and follow-up of community-based prospective cohort: Hypertension group: (1) secondary hypertension (such as renal, endocrine, etc.); (2) recovery period after severe cardiovascular and cerebrovascular events (myocardial infarction, stroke, etc., within the past 3 months); (3) complicated with malignant tumors, severe infectious diseases, severe hematological diseases (leukemia or lymphoma), severe liver and kidney failure, active tuberculosis, etc. (4) mental disorder or severe cognitive impairment, unable to cooperate with the investigation; (5) pregnancy or lactation; (6) those who participated in other clinical trials within 1 month; (7) those who were judged by the study doctors to be unsuitable for inclusion. Control group: (1) blood pressure >=140/90 mmHg at any time point; (2) recovery period after severe cardiovascular and cerebrovascular events (myocardial infarction, stroke, etc., within the past 3 months); (3) complicated with malignant tumors, severe infectious diseases, severe hematological diseases (leukemia or lymphoma), severe liver and kidney failure, active tuberculosis, etc. (4) mental disorder or severe cognitive impairment, unable to cooperate with the investigation; (5) pregnancy or lactation; (6) those who participated in other clinical trials within 1 month; (7) those who were judged by the study doctors to be unsuitable for inclusion. 2. Studies on lifestyle intervention in extremely high risk population of hypertension: (1) medical contraindications restricting exercise or dietary modification; (2) not cooperating with or refusing behavioral intervention; (3) patients who had received other antihypertensive interventions. 3. Mechanism research: omics analysis of blood markers: (1) samples were collected over the time limit or stored improperly; (2) complicated with severe chronic inflammatory diseases or other diseases affecting metabolic status; (3) The same subject participated in other mechanistic researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Target organ damage;Blood Pressure Control Rate (proportion of patients with office systolic blood pressure SBP <140 mmHg and diastolic blood pressure DBP <90 mmHg); | — |
Secondary
| Measure | Time frame |
|---|---|
| Differential Expression of Biomarkers;Improvement Rate in Medication Adherence;Cumulative Incidence of Cardio-Cerebrovascular Events; | — |
Countries
China
Contacts
Public ContactJunnan Tang
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed