Urethral repair and reconstruction surgery
Conditions
Interventions
Oliceridine group:None
Sponsors
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Adult male patients undergoing elective urethral repair and reconstruction surgery under general anesthesia
Exclusion criteria
Exclusion criteria: 1. BMI > 30 kg/m^2; 2. Analgesic pump programming strategy accommodates both weight-based and fixed-dose scenarios; 3. Inability to comprehend numerical rating scales for pain assessment; 4. Long-term opioid use or opioid tolerance; 5. Severe impairment of cardiac, pulmonary, hepatic, or renal function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of moderate to severe pain at rest during the first 72 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain scores at rest and during movement;Time of first postoperative rescue analgesia and number of rescue analgesia episodes;Patient satisfaction scores for postoperative analgesia;Postoperative nausea and vomiting grading;Postoperative respiratory depression and subclinical respiratory depression;Ramsay sedation scale;Athens insomnia scale (AIS) score;The score of the Europe Health-Related Quality of Life Questionnaire 5 Dimensions (EQ-5D);Time of first ambulation after surgery;Safety indicators (including: nausea and vomiting, respiratory depression, hypotension, hypertension, tachycardia, bradycardia, excessive sedation, pruritus, dizziness, constipation, fever, chills, restlessness during the recovery period, dry mouth, abdominal distension, bladder spasm, etc.; | — |
Countries
China
Contacts
Public ContactDong Yushan
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed