Peripheral vascular disease
Conditions
Interventions
Training set:None
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: Phase I Study (Multicenter Retrospective Study, Experimental Cohort) Inclusion criteria: Age >= 35 years;Patients with chronic lower limb ischemia who underwent interventional surgery;Having preoperative lower limb CTA imaging results and blood samples. Phase II Study (Multicenter Prospective Study, Validation Cohort) Inclusion criteria: Age >= 35 years;Chronic lower limb ischemia at Rutherford stage 3-5;Undergoing interventional therapy;Patients who provided informed consent for enrollment;Capable of completing optimal medical treatment.
Exclusion criteria
Exclusion criteria: Phase I Study (Multicenter Retrospective Study, Experimental Cohort) Exclusion criteria: Patients with a history of lower limb amputation;Acute lower limb ischemia;Poor quality of CTA images that affects the interpretation of the observation area;Lack of blood samples or incomplete relevant case data required for the study. Phase II Study (Multicenter Prospective Study, Validation Cohort) Exclusion criteria: Age < 35 years;Acute lower limb ischemia;Chronic lower limb ischemia at Rutherford stage 6;Patients with a history of lower limb amputation;Patients scheduled to undergo lower limb amputation surgery;Patients scheduled to undergo open bypass surgery;Inability to complete CTA examination;Inability to cooperate with follow-up;Contrast medium contraindication; Hepatic and renal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood routine examination;Blood biochemistry;Coagulation Function;Ankle-Brachial Index;Electrocardiogram;Quality of Life (QoL) Scale Score;Adverse Limb Events;Degree of Stenosis of vessel; Plaque Burden;Plasma Metabolomics;Plasma Proteomics;Basic Information Related to Surgery;Basic Information Related to Anesthesia;Surgery and Anesthesia-Related Complications;Duration of Hospitalization;Hospitalization Expenses;Cardiovascular and Cerebrovascular Events;Systemic Complications;Adverse Limb Events;Medication During the Follow-Up Period;Symptom Recurrence;Target Vessel Patency;Healing Status of Lower Extremity Gangrene and Ulcers;Amputation Status;Time for Five Sit-Ups;6-Minute Walk Test;Death event;Indicators for Lower Extremity Muscles;Area under the ROC curve; | — |
Secondary
| Measure | Time frame |
|---|---|
| Calibration Curve;Positive Predictive Value;Negative Predictive Value; | — |
Countries
China
Contacts
Public ContactDiao Yongpeng
Beijing Hospital
Outcome results
None listed