Maternal Gut Dysbiosis Triggers Immune Overactivation in Preeclampsia, leading to Offspring Neurodevelopmental Disorders

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600118256

Enrollment

Unknown

Registered

2026-02-03

Start date

2026-02-03

Completion date

Unknown

Last updated

2026-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preeclampsia

Interventions

Preeclampsia with offspring autism group:none

Normal pregnancy with normal offspring group:None

Eligibility

Sex/Gender

Female

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Single gestation; 2. Age 20–45 years; 3. Gestational age 32–36 weeks; 4. Pre-eclampsia group meeting international diagnostic criteria (new-onset hypertension with proteinuria after 20 weeks of gestation); 5. Control group comprising women with concurrent uncomplicated pregnancies and no gestational complications.

Exclusion criteria

Exclusion criteria: 1.Multiple pregnancy; 2.Pre-existing chronic hypertension, diabetes, or kidney disease; 3.Recent use of antibiotics or probiotics (within 4 weeks); 4.Presence of other pregnancy complications; 5.Refusal to sign informed consent;

Design outcomes

Primary

Measure	Time frame
Serum metabolite profile;Gut microbiota profile;Serum inflammatory cytokine levels;	—

Countries

China

Contacts

Public ContactWenlong Zhao

Hangzhou Women's Hospital

zwlzby-09@163.com+86 576 56005077

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 15, 2026