Depressive disorder
Conditions
Interventions
Depressive Disorder Group:No intervention
Healthy Control Group:No intervention
Sponsors
Wuxi Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for depressive disorder as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) (MDD group). 2.Undergo screening via semi-structured clinical interviews to exclude subjects with psychiatric disorders (HC group). 3.Be of Chinese Han ethnicity, with no restrictions on gender. 4.Aged 18–65 years old and right-handed. 5.Have an educational level of primary school or above. 6.Be able to undergo examinations including electroencephalography (EEG), blood sampling, and fecal sample collection. 7.Have not taken prebiotics, probiotics, or antibiotics within one month prior to enrollment.
Exclusion criteria
Exclusion criteria: 1.Comorbidities of other psychiatric disorders (e.g., bipolar disorder, schizophrenia, substance dependence), or poorly controlled severe physical illnesses such as coronary heart disease and thyroid dysfunction. 2.A history of craniocerebral trauma leading to loss of consciousness, or a history of epilepsy. 3.Presence of uncorrectable visual or auditory impairment that cannot be ameliorated to a basically normal level. 4.Presence of obvious finger motor dysfunction (unable to operate a computer mouse). 5.Women who are pregnant or lactating, or individuals who are planning pregnancy or child-rearing. 6.Having received electroconvulsive therapy (ECT)/modified electroconvulsive therapy (MECT) within the past 6 months. 7.A history of allergies to electrode patches, or a phobia of blood or needle sticks. 8.Refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electroencephalography (EEG) detection;Short-Chain Fatty Acids;Gut Microbiota;Blood test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammation-associated Cytokines;HAMA-14?HAMD-17; | — |
Countries
China
Contacts
Public ContactXia Wenjuan
Wuxi Mental Health Center
Outcome results
None listed