Postoperative Nausea and Vomiting
Conditions
Interventions
Group A (dexamethasone + ondansetron):None
Group B (Dexamethasone + Fluphenazine):None
Group C (Dexamethasone + Pethidine Hydrochloride):None
Sponsors
The Affiliated Hospital of Jining Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–65 years; 2. Patients scheduled for gynecological laparoscopic surgery under general anesthesia (laparoscopic ovarian and/or fallopian tube surgery, hysterectomy and/or myomectomy, uterine lesion removal); 3. BMI 18.5–28 kg/m^2; 4. ASA classification I–II; 5. No history of drug allergies; 6. Patients and their families are informed and give consent, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe infection, severe heart failure, or liver and kidney dysfunction before surgery; 2. Use of antiemetic drugs, glucocorticoids, or psychiatric medications within 24 hours before surgery that are known to affect the occurrence of PONV; 3. History of chronic pain, long-term use of analgesics or psychiatric medications (including opioids, NSAIDs, and antidepressants); 4. History of radiotherapy or chemotherapy before surgery; 5. Diabetes; 6. Severe hearing impairment, language expression disorders, or mental illness, making patient unable to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting;Postoperative nausea and vomiting severity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Salvage antiemetics use;Restore quality Q15;The time of the first postoperative flatus;Incidence of adverse events;Postoperative pain score (at rest and when coughing and swallowing); | — |
Countries
China
Contacts
Public ContactLi Yandong
The Affiliated Hospital of Jining Medical University
Outcome results
None listed