Sepsis-Associated Acute Respiratory Distress Syndrome
Conditions
Interventions
Interventional Group :Dissolve 100 mL of Xuebijing Injection in 100 mL of 0.9% sodium chloride solution, and administer by intravenous drip over 30-40 minutes, every 12 hours, for 5 consecutive days.
Control Group:Conventional treatment was applied.
Sponsors
Su Bei People's Hospital, Jiangsu Province
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Adult patients admitted to the ICU, aged >= 18 years; 2.Meeting the diagnostic criteria for Sepsis 3.0; 3.Meeting the diagnostic criteria for sepsis-associated ARDS; 4.Patients or their family members have provided informed consent.
Exclusion criteria
Exclusion criteria: 1.Diagnosis of sepsis for more than 48 hours; 2.Informed consent not provided; 3.Expected survival of less than 48 hours; 4.Severe hepatic or renal dysfunction (defined as a SOFA subscore of >=3 for either the liver or kidney); 5.Current or recent (within 30 days) use of antibiotic therapy or immunosuppressive therapy (including corticosteroids); 6.Participation in other clinical trials within the past 30 days; 7.Pregnancy or lactation; 8.Known allergy to any component of Xuebijing Injection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in respiratory indices;Cytokines;Hemodynamic parameters;Norepinephrine dosage;SOFA score;APACHE II score;Duration of mechanical ventilation during hospitalization;ICU length of stay;Hospital length of stay;28-day mortality; | — |
Countries
China
Contacts
Public ContactZheng Ruiqiang
Su Bei People's Hospital, Jiangsu Province
Outcome results
None listed