Refractory depressive disorder
Conditions
Interventions
MECT experimental grou:Modified electroconvulsive therapy
Drug treatment control group:Conventional drug treatment
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for ICD-10/DSM-5 depression; 2. The age range is 18-65; 3. HAMD-17 score >=24 points and Young's Mania Scale score <=7 points; 4. There was no ECT or Repetitive transcranial magnetic stimulation (rTMS) during the first 4 weeks of treatment; 5. Signed informed consent, in the observation time can visit on time, this study has a good compliance; 6. Non-literate, able to complete the scale tests independently and understand the content of the scale.
Exclusion criteria
Exclusion criteria: 1. Symptoms of depression with organic disease or other mental disorders; 2. Have a serious physical disease, disease of the immune and endocrine systems, a recent infection or vaccination; 3. Bipolar disorder or history of other mental illness, alcohol or substance abuse; 4. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complement C1q;C-reactive protein;Interleukin-6; | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive function;Depression severity;Clinical efficacy and side effects;Information related to MECT; | — |
Countries
China
Contacts
Public ContactYuanhong Shi
Northern Jiangsu People's Hospital
Outcome results
None listed