Oral malignant tumors include tongue cancer, buccal cancer, and gingival cancer.
Conditions
Interventions
GDFT group (Group G):After entering the room, 5 mL/kg/h crystalloid solution was used as the basic infusion volume. SVV and SVRI were dynamically evaluated every 15 minutes: if 7% 65mmHg, HR>45 beats
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.American Society of Anesthesiologists (ASA) classification I to III; 2. age >=50 years old and =20 kg/m ² and <=30kg/m ²; 3.A radical resection of oral cancer with flap transplantation is proposed;
Exclusion criteria
Exclusion criteria: 1.There are cardiovascular diseases such as heart failure, arrhythmia, poorly controlled hypertension and coronary heart disease; 2.Renal insufficiency (preoperative serum creatinine >141umol/L); 3.Intraoperative blood loss > 1,000 mL; 4.Those who have adverse reactions such as allergies to the test drugs; 5. Those who have cognitive dysfunction before the operation; 6.Those who are unwilling to complete the test process or cannot understand the test;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Record the time of postoperative awakening and extubation, the length of stay in the ICU, the time of discharge, the levels of white blood cells and serum creatinine at 24 hours and 72 hours after the operation, the postoperative wound drainage volume, the incidence of hypotension, and the occurrence of adverse events of the transplanted flap. The incidence of postoperative complications such as heart (24-hour postoperative BNP, lower extremity edema), lung (pulmonary edema, atelec; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative: Record the heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and arterial blood lactate level at the time of entering the operating room (T1), 1 hour after the operation (T2), 2 hours after the operation (T3), 4 hours after the operation (T4), and the end of the operation (T5). Record the total duration of the operation, total fluid intake, colloid intake, crystal intake, blood transfusion volume, urine volume, and blood loss;Preoperative: Baseline data of the two groups of patients were collected, including: gender, age, ASA classification, height, weight, BMI, preoperative tests and examinations (electrocardiogram, creatinine level, lung CT/ X-ray, echocardiography), past medical history, type of surgery, etc. Baseline T0 vital signs (heart rate, blood pressure, blood oxygen saturation) were recorded.; | — |
Countries
China
Contacts
Public ContactXiao Feng
The Second Xiangya Hospital of Central South University
Outcome results
None listed