Overweight Patients with Early Type 2 Diabetes
Conditions
Interventions
Trial Group 1:Calorie-Restricted Balanced Diet (CRBD) Intervention
Trial Group 2:Calorie- and carbohydrate-restricted dietary intervention
Control Group:Target-Energy Balanced Dietary Intervention
Sponsors
Ningbo No.2 Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with type 2 diabetes mellitus according to the 1999 World Health Organization diagnostic criteria, aged 18 to 60 years (inclusive); 2.Disease duration =1.1 ng/ml and 2-hour postprandial C-peptide >=2.5 ng/ml; 3.Body mass index (BMI) >=25.0 kg/m² (or waist circumference >90 cm for males, >85 cm for females); 4.Provision of informed consent for participation in this study.
Exclusion criteria
Exclusion criteria: 1.Patients with mental disorders that preclude understanding or cooperation with the study. Presence of conditions associated with shortened red blood cell lifespan (e.g., sickle cell anemia, thalassemia) or any disease affecting the accuracy of glycated hemoglobin (HbA1c) measurement. Patients who are pregnant. Comorbidities including severe cardiovascular disease (CVD), malignancy, severe retinopathy, renal disease, or other significant chronic conditions. Use of insulin therapy within the past month. Weight loss of =5% within the previous month. Current use of weight-loss medications (glucagon-like peptide-1 receptor agonists and orlistat). Patients likely to relocate within 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remission Rate and Maintenance Status of Type 2 Diabetes Mellitus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ectopic fat deposition;Beta-cell function;Insulin resistance;Lipid profile;Complications related to diabetes (diabetic retinopathy, diabetic nephropathy, peripheral neuropathy, CVD); | — |
Countries
China
Contacts
Public ContactChen Yu
Ningbo No.2 Hospital
Outcome results
None listed