None
Conditions
Interventions
Control group:The control group was given routine care. All medical and nursing work must follow the basic requirements and principles related to disinfection, sterilization and hospital infection con
Intervention group:On the basis of implementing nursing measures in the control group, the intervention group was carried out by nursing staff who obtained the certificate of thoracic physical therapi
Sponsors
the Second Medical Center, PLA Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients who received mechanical ventilation in the surgical ICU and hepatobiliary surgery ICU of the First Medical Center were selected as the research subjects. Inclusion criteria 1. Age > 18 years old; 2. Patients who underwent mechanical ventilation with tracheal intubation for the first time; 3. Mechanical ventilation >=24 hours; 4. Stable cardiovascular system: Heart rate 60-120 beats per minute; Systolic blood pressure: 90-180 MMHG (1mmHg=0.133kPa); Support with low-dose vasoactive drugs, with dopamine =90%; During mechanical ventilation, the inhaled oxygen concentration (FiO2) was less than 60% and the positive end-expiratory pressure (PEEP) was less than or equal to 10cmH2O. The tracheal intubation was properly fixed.
Exclusion criteria
Exclusion criteria: 1.Patients with neuromuscular diseases requiring mechanical ventilation to maintain breathing, acute stroke, spinal cord injury, suspected or confirmed myogenic diseases or neurogenic muscle weakness; 2. Onset of mental illness or presence of audio-visual impairment, unable to cooperate; 3. Patients with extensive trauma all over the body and cardiac arrest; 4. Terminally ill or requiring immediate transfer to another hospital for treatment; 5. Respiratory failure caused by central nervous system diseases; 6. Patients who are unable to undergo chest physical therapy for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of VAP;Mechanical ventilation time (h); | — |
Secondary
| Measure | Time frame |
|---|---|
| cst;CD4+T cell subsets (Th17, Treg) and cytokines (IL-6, IL-10, IL-17, STAT3, Foxp3, ROR?t) in peripheral blood.;MUC5AC and SP-D proteins in sputum.; | — |
Countries
China
Contacts
Public ContactZheng Luo
Department of Respiratory and Critical Care Medicine, the Second Medical Center, PLA Hospital
Outcome results
None listed